The latest 3.4 release of Cyberduck now supports the configuration of Amazon CloudFront streaming distributions. A dropdown menu in the Info panel allows to choose between traditional basic HTTP distributions and the new RTMP streaming distributions supported.
The help section will be edited with updated instructions soon altough the configuration should be straightforward. In the meantime refer to the official Amazon documentation on streaming distributions.
It probably has never been easier to distribute a video in the CDN for streaming with a click of a button.